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Description for Protein SGK1

serum/glucocorticoid regulated kinase 1
36 total interacting proteins; 21 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
  • S_T_Y_Kinase: Protein kinase
  • unclassified specificity
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K13302
    KEGG - Pathway(s):
    hsa04960
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    SGK1; Serine/threonine protein kinase SGK; Serine/threonine-protein kinase SGK1; Serum/glucocorticoid-regulated kinase 1
    Approved Symbol:
    SGK1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 32
    Human (de-) phosphorylation sites: 32; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 20
    Human phosphorylation targets: 19; Predicted platelet targets: 1
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid(db);
  • Riboflavin Monophosphate(db);
  • [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04264 Entrez Gene ID: 6446 OMIM ID: 602958 Swissprot Accession: O00141;