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Description for Protein SFTPB

surfactant protein B
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • SAPB: Saposin (B) Domains
  • SAPA: Saposin/surfactant protein-B A-type DOMAIN
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Surfactant, pulmonary associated protein B; Surfactant associated protein, pulmonary 3; SFTP3; SFTPB3; Pulmonary surfactant apoprotein PSP-B; PSP-B; SP-B; Pulmonary surfactant associated protein, 18-KD; Pulmonary surfactant associated proteolipid SPL(Phe); 6 kDa protein; Pulmonary surfactant-associated protein B; 18 kDa pulmonary-surfactant protein
    Approved Symbol:
    SFTPB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Pulmonary alveolar proteinosis, congenital(Pd);
  • Pulmonary alveolar proteinosis, congenital, with misalignment of lung vessels(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01523 Entrez Gene ID: 6439 OMIM ID: 178640 Swissprot Accession: P07988;