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Description for Protein RGNEF

190 kDa guanine nucleotide exchange factor
6 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants. (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • PH: Pleckstrin homology domain.
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • RHOGEF: Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    FLJ21817 protein; KIAA1998 protein; RGNEF
    Approved Symbol:

    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 15244 Entrez Gene ID: 64283 OMIM ID: 612790 Swissprot Accession: C9J1V7;