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Description for Protein SRSF1

serine/arginine-rich splicing factor 1
39 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 13. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RRM: RNA recognition motif
  • ARM: Armadillo/beta-catenin-like repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12890
    KEGG - Pathway(s):
    hsa03040
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Pre mRNA splicing factor SF2, P33 subunit; Alternative splicing factor ASF 1; Splicing factor 2; Splicing factor, arginine/serine rich, 30KD, A; SF2P33; ASF; SF2; SRp30a; Splicing factor, arginine/serine-rich 1 isoform 2
    Approved Symbol:
    SRSF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 27
    Human (de-) phosphorylation sites: 27; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02887 Entrez Gene ID: 6426 OMIM ID: 600812 Swissprot Accession: Q07955; Q59FA2;