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Description for Protein SELP

selectin P (granule membrane protein 140kDa, antigen CD62)
11 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/1)
(alpha granules: 2; membrane: 1; microparticles: 1; platelet: 5; secretome: 3; undefined: 1)
Summary:
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • EGF: Epidermal growth factor-like domain.
  • SUSHI: Sushi domain (SCR repeat)
  • LECTIN_C: C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06496
    KEGG - Pathway(s):
    hsa04514; hsa05144
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Platelet alpha granule membrane protein; CD62; Granulocyte membrane protein; GRMP; GMP 140; PSGL-1
    Approved Symbol:
    SELP
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1na(db);
  • 2-Methyl-2,4-Pentanediol(db);
  • Fucose(db);
  • Heparin(db);
  • O-Sialic Acid(db)

    Associated Genetic Diseases:

  • Atopy, susceptibility to(Pd);
  • Selectin p polymorphism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01433 Entrez Gene ID: 6403 OMIM ID: 173610 Swissprot Accession: P16109; Q5R349; Q6NUL9;