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Description for Protein SELL

selectin L
15 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • EGF: Epidermal growth factor-like domain.
  • SUSHI: Sushi domain (SCR repeat)
  • TM: Transmembrane domain
  • LECTIN_C: C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06495
    KEGG - Pathway(s):
    hsa04514
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    LSEL; Leu-8 antigen; CD62L antigen; Lymphocyte adhesion molecule 1; LYAM1; LAM1; LEU8; CD62 antigen ligand; LNHR; hLHRc; Leu-8; Lyam1; PLNHR; CD62L; Lymph node homing receptor; Leukocyte adhesion molecule 1; Leukocyte surface antigen Leu8; TQ1; gp90-MEL; Leukocyte endothelial cell adhesion molecule 1; LECAM1; HLHRC
    Approved Symbol:
    SELL
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 07034 Entrez Gene ID: 6402 OMIM ID: 153240 Swissprot Accession: P14151; Q9UJ43;