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Description for Protein NECAB3

N-terminal EF-hand calcium binding protein 3
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • EF: EF-hand, calcium binding motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Amyloid beta A4 protein binding family A member 2 binding protein; Neuronal calcium binding protein NECAB3; Nek2 interacting protein 1; NIP1; Synaptotagmin interacting protein STIP3; Synaptotagmin interacting protein 2; XB51; Amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein isoform 1; Amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein isoform 2; NECAB3; SYTIP2; dJ63M2.4; dJ63M2.5; EFCBP3
    Approved Symbol:
    NECAB3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07168 Entrez Gene ID: 63941 OMIM ID: 612478 Swissprot Accession: Q96P71;