Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein SDHD

succinate dehydrogenase complex, subunit D, integral membrane protein
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The subunit D protein is one of two integral membrane proteins anchoring the complex to the matrix side of the membrane. Mutations in SDHD have been linked to hereditary paraganglioma. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.3.5.1
KEGG - Orthology:
K00237
KEGG - Pathway(s):
hsa00020; hsa00190; hsa01100; hsa05010; hsa05012; hsa05016
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
SDH4; Succinate dehydrogenase complex, subunit D
Approved Symbol:
SDHD
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol(db);
  • Hexachlorophene(db);
  • Succinic acid(db);
  • UBIQUINONE-1(db)

    Associated Genetic Diseases:

  • Carcinoid tumors, intestinal(Pd);
  • Paraganglioma, carotid body, somatic(Pd);
  • Paragangliomas 1(Pd);
  • Paragangliomas with sensorineural hearing loss(Pd);
  • Pheochromocytoma(Pd);
  • Sdhd polymorphism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04069 Entrez Gene ID: 6392 OMIM ID: 602690 Swissprot Accession: O14521;