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Description for Protein SDHC

succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. Several related pseudogenes are located in different genomic regions. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.3.5.1
    KEGG - Orthology:
    K00236
    KEGG - Pathway(s):
    hsa00020; hsa00190; hsa01100; hsa05010; hsa05012; hsa05016
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CYBL; Succinate dehydrogenase 3, integral membrane subunit; SDH3; QPS1; Integral membrane protein C2-3; Succinate ubiquinone oxidoreductase cytocrome B large subunit; Succinate dehydrogenase complex, subunit C, integral membrane protein, 15KD; CYB560; Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; PGL3; Integral membrane protein CII-3b; Cytochrome B large subunit of complex II; Succinate dehydrogenase complex, subunit C isoform 2 precursor; Succinate dehydrogenase complex, subunit C isoform 3 precursor; Succinate dehydrogenase complex, subunit C isoform 4 precursor; Succinate dehydrogenase complex, subunit C isoform 1 precursor
    Approved Symbol:
    SDHC
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol(db);
  • Succinic acid(db);
  • UBIQUINONE-1(db)

    Associated Genetic Diseases:

  • Paragangliomas, 3(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 3
  • Isoform 3 : 3
  • Isoform 2 : 0
  • Isoform 1 : 3
    • Additional Identifiers:

    HPRD: 03878 Entrez Gene ID: 6391 OMIM ID: 602413 Swissprot Accession: Q3C2D8; Q99643; O75609;