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Description for Protein SDHB

succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.3.5.1
    KEGG - Orthology:
    K00235
    KEGG - Pathway(s):
    hsa00020; hsa00190; hsa01100; hsa05010; hsa05012; hsa05016
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Succinate dehydrogenase 1, iron sulfur subunit; SDH1; Succinate dehydrogenase iron-sulfur protein, mitochondrial; Succinate dehydrogenase complex, subunit B, iron sulfur; Iron-sulfur subunit of complex II; Ip; SDH; SDHIP
    Approved Symbol:
    SDHB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol(db);
  • Succinic acid(db);
  • UBIQUINONE-1(db)

    Associated Genetic Diseases:

  • Paragangliomas 4(Pd);
  • Pheochromocytoma(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01707 Entrez Gene ID: 6390 OMIM ID: 185470 Swissprot Accession: P21912;