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Description for Protein SDHA

succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(microparticles: 1; platelet: 5)
Summary:
This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.3.5.1
KEGG - Orthology:
K00234
KEGG - Pathway(s):
hsa00020; hsa00190; hsa01100; hsa05010; hsa05012; hsa05016
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Flavoprotein subunit of complex 2; SDH2; FP; SDHF; Succinate dehydrogenase complex, subunit A, flavoprotein
Approved Symbol:
SDHA
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 4
Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol(db);
  • Carboxin(db);
  • Succinic acid(db);
  • Thenoyltrifluoroacetone(db);
  • UBIQUINONE-1(db)

    Associated Genetic Diseases:

  • Leigh syndrome due to mitochondrial complex II deficiency(Pd);
  • Mitochondrial complex II deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02914 Entrez Gene ID: 6389 OMIM ID: 600857 Swissprot Accession: P31040;