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Description for Protein CXCL12

chemokine (C-X-C motif) ligand 12
10 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • SCY: Intercrine alpha family (small cytokine C-X-C) (chemokine CXC).
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10031
    KEGG - Pathway(s):
    hsa04060; hsa04062; hsa04360; hsa04670; hsa04672
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PBSF; SCYB12; SDF 1a; SDF 1b; TPAR1; SDF1; TLSF-a; TLSF-b; Chemokine; Stromal cell derived factor 1; Stromal cell derived factor 1 gamma; Stromal cell derived factor 1a; Chemokine ligand 12 isoform alpha; Pre B cell growth stimulating factor; hIRH; SDF 1 beta; SDF 1 alpha; Chemokine ligand 12 isoform gamma; Chemokine ligand 12 isoform beta
    Approved Symbol:
    CXCL12
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Human immunodeficiency virus type 1, resistance to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02904 Entrez Gene ID: 6387 OMIM ID: 600835 Swissprot Accession: P48061; Q5IT36; Q6ICW0;