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Description for Protein BID

BH3 interacting domain death agonist
34 total interacting proteins; 17 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/0)
(membrane: 1; microparticles: 1; platelet: 7; secretome: 2)
Summary:
This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04726
    KEGG - Pathway(s):
    hsa04115; hsa04210; hsa04650; hsa05010; hsa05014; hsa05200; hsa05416
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    BH3 interacting domain death agonist isoform 1; BH3 interacting domain death agonist isoform 3; BH3 interacting domain death agonist isoform 2
    Approved Symbol:
    BID
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03590 Entrez Gene ID: 637 OMIM ID: 601997 Swissprot Accession: B3KT21; P55957; B2ZP79;