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Description for Protein CCL23

chemokine (C-C motif) ligand 23
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist at CC chemokine receptor 1. Two alternatively spliced variants encoding different active isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • SCY: Intercrine alpha family (small cytokine C-X-C) (chemokine CXC).
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05511
    KEGG - Pathway(s):
    hsa04060; hsa04062
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Small inducible cytokine subfamily A, member 23; Myeloid progenitor inhibitory factor 1; MPIF1; SCYA23; CK beta 8; Small inducible cytokine A23; MIP3; CKB8; Macrophage inflammatory protein 3; Ckb-8-1; C6 beta-chemokine; hmrp-2a; Small inducible cytokine A23 isoform CKbeta8-1 precursor; Small inducible cytokine A23 isoform CKbeta8 precursor
    Approved Symbol:
    CCL23
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03930 Entrez Gene ID: 6368 OMIM ID: 602494 Swissprot Accession: P55773;