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Description for Protein CCL5

chemokine (C-C motif) ligand 5
18 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/1)
(alpha granules: 1; microparticles: 1; platelet: 2)
Summary:
This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • SCY: Intercrine alpha family (small cytokine C-X-C) (chemokine CXC).
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12499
    KEGG - Pathway(s):
    hsa04060; hsa04062; hsa04620; hsa04621; hsa04623; hsa05020; hsa05120; hsa05142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    RANTES; Small inducible cytokine A5; T cell specific RANTES protein; SCYA5; T cell specific protein p228; TCP228; CC chemokine ligand 5; SIS-delta
    Approved Symbol:
    CCL5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Heparin Disaccharide I-S(db);
  • Heparin Disaccharide Iii-S(db)

    Associated Genetic Diseases:

  • Human immunodeficiency virus type 1, delayed disease progression with infection by(Pd);
  • Human immunodeficiency virus type 1, rapid disease progression with infection by(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01751 Entrez Gene ID: 6352 OMIM ID: 187011 Swissprot Accession: P13501; D0EI67;