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Description for Protein SCP2

sterol carrier protein 2
5 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.3.1.176
KEGG - Orthology:
K08764
KEGG - Pathway(s):
hsa00120; hsa01100; hsa03320; hsa04146
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
SCPX; Sterol carrier protein X; Nonspecific lipid transfer protein mitochondrial; NSL TP; Sterol carrier protein 2 isoform 1 proprotein; Sterol carrier protein 2 isoform 1 precursor; Sterol carrier protein 2 isoform 2 precursor; Sterol carrier protein 2 isoform 3 precursor; NLTP; Nonspecific lipid-transfer protein; SCP-2; Sterol carrier protein 2 isoform 2
Approved Symbol:
SCP2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 6
Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Leukoencephalopathy with dystonia and motor neuropathy, SCPX-deficient(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01700 Entrez Gene ID: 6342 OMIM ID: 184755 Swissprot Accession: P22307; Q6NXF4; A6NM69;