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Description for Protein SCN10A

sodium channel, voltage-gated, type X, alpha subunit
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Voltage-gated sodium channels are integral membrane glycoproteins that are responsible for the initial rising phase of action in most excitable cells. They are composed of a large alpha subunit that may be associated with one or more smaller beta subunits. Sodium channels can be differentiated by their primary structure, kinetics, and relative sensitivity to the neurotoxin tetrodotoxin (TTX). Sodium channels, particularly those with TTX-resistant currents, have been found to accumulate in the region of peripheral nerve injury and may be important in chronic pain. SCN10A encodes a TTX-resistant channel that is restricted to the peripheral sensory nervous system (Rabert et al., 1998 [PubMed 9839820]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04842
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    hPN3; Tetrodotoxin resistant voltage gated sodium channel; Voltage gated sodium channel alpha subunit Nav1.8; Peripheral nerve sodium channel 3
    Approved Symbol:
    SCN10A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Benzocaine(db);
  • Bupivacaine(db);
  • Chloroprocaine(db);
  • Cocaine(db);
  • Dibucaine(db);
  • Dyclonine(db);
  • Hexylcaine(db);
  • Levobupivacaine(db);
  • Lidocaine(db);
  • Mepivacaine(db);
  • Orphenadrine(db);
  • Oxybuprocaine(db);
  • Procaine(db);
  • Proparacaine(db);
  • Ropivacaine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
    09188_1(20)
    Additional Identifiers:

    HPRD: 09188 Entrez Gene ID: 6336 OMIM ID: 604427 Swissprot Accession: Q9Y5Y9;