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Description for Protein SCN3A

sodium channel, voltage-gated, type III, alpha subunit
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • TM: Transmembrane domain
  • IQ: Short calmodulin-binding motif containing conserved Ile and Gln residues.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04836
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Sodium channel, brain type III, alpha; NAC3; Voltage gated sodium channel subtype III; Sodium channel, voltage gated, type III, alpha polypeptide; Sodium channel, voltage-gated, type III, alpha isoform 2; Sodium channel, voltage-gated, type III, alpha isoform 1; Sodium channel, voltage-gated, type III, alpha isoform 3
    Approved Symbol:
    SCN3A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Zonisamide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
    01671_3(20)
    01671_2(20)
    01671_1(20)
    Additional Identifiers:

    HPRD: 01671 Entrez Gene ID: 6328 OMIM ID: 182391 Swissprot Accession: Q9NY46; Q9C007;