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Description for Protein SCN2A1

Sodium channel, voltage gated, type II, alpha 1 subunit
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
In many cell types the sodium channel is responsible for generation and propagation of action potentials, chiefly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large glycosylated alpha subunit (approximately 260 kD) and 2 smaller beta subunits (33-39 kD). The transmembrane alpha subunit is responsible for the functional activity of the channel (Litt et al., 1989). In the brain, there are 4 different alpha-subunit genes encoding 3 main subunits: types I (SCN1A; MIM 182389), II (SCN2A1 and SCN2A2; MIM 601219), and III (SCN3A; MIM 182391). Of these, the type II sodium channel mRNA is the most abundant (Litt et al., 1989).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
None Available
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
-
Approved Symbol:

(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
01670_1(17)
Additional Identifiers:

HPRD: 01670 Entrez Gene ID: 6325 OMIM ID: - Swissprot Accession: -