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Description for Protein MAPK12

mitogen-activated protein kinase 12
19 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 4)
Summary:
Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.24
    KEGG - Orthology:
    K04441
    KEGG - Pathway(s):
    hsa04010; hsa04114; hsa04370; hsa04620; hsa04621; hsa04622; hsa04660; hsa04664; hsa04670; hsa04722; hsa04912; hsa04914; hsa05014; hsa05120; hsa05131; hsa05140; hsa05142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Mitogen activated protein kinase 12; Extracellular signal regulated kinase 6; ERK6; Stress activated protein kinase 3; SAPK3; p38 gamma
    Approved Symbol:
    MAPK12
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 7
    Human phosphorylation targets: 7; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Phosphoaminophosphonic Acid-Adenylate Ester(db);
  • Phosphonothreonine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03868 Entrez Gene ID: 6300 OMIM ID: 602399 Swissprot Accession: P53778;