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Description for Protein SAFB

scaffold attachment factor B
19 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a DNA-binding protein that has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. This encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of the heat shock protein 27 transcription and also can act as an estrogen receptor corepressor. This gene is a candidate gene for breast tumorigenesis. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SAP: Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
  • RRM: RNA recognition motif
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    SAFB1; HET; Hsp27 ere-TATA-binding protein; Glutathione S-transferase fusion protein; Heat shock protein estrogen response element and TATA box-binding protein; Hsp27 estrogen response element and TATA box-binding protein; hnRNP A1 associated protein
    Approved Symbol:
    SAFB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 49
    Human (de-) phosphorylation sites: 49; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04205 Entrez Gene ID: 6294 OMIM ID: 602895 Swissprot Accession: Q15424;