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Description for Protein BDNF

brain-derived neurotrophic factor
11 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04355
    KEGG - Pathway(s):
    hsa04010; hsa04722; hsa05016
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Brain-derived neurotrophic factor isoform a preprotein; Brain-derived neurotrophic factor isoform b; Brain-derived neurotrophic factor isoform c; Hypothetical protein MGC34632; Neurotrophin
    Approved Symbol:
    BDNF
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Bulimia nervosa, age of onset of weight loss in(Pd);
  • Central hypoventilation syndrome, congenital(Pd);
  • Memory impairment, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
    00214_18(0)
    00214_17(0)
    00214_16(0)
    00214_15(0)
    00214_14(0)
    00214_13(0)
    00214_12(0)
    00214_11(0)
    00214_10(0)
  • Isoform 9 : 0
  • Isoform 8 : 0
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 1
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00214 Entrez Gene ID: 627 OMIM ID: 113505 Swissprot Accession: P23560;