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Description for Protein RYK

RYK receptor-like tyrosine kinase
5 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • Tyr_Kinase: tyrosine kinase domain
  • WIF: Wnt-inhibitory factor-1 like domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.1
    KEGG - Orthology:
    K05128
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    RYK1; Tyrosylprotein kinase; Hydroxyaryl protein kinase; JTK5; JTK5A; D3S3195; JTK5A protein tyrosine kinase; RYK receptor-like tyrosine kinase isoform 1; RYK receptor-like tyrosine kinase isoform 2
    Approved Symbol:
    RYK
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 02751 Entrez Gene ID: 6259 OMIM ID: 600524 Swissprot Accession: Q8WTZ8; P34925; Q59FQ5;