Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein RRM2

ribonucleotide reductase M2
6 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.17.4.1
KEGG - Orthology:
K10808
KEGG - Pathway(s):
hsa00230; hsa00240; hsa00480; hsa01100; hsa04115
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Ribonucleotide reductase M2 polypeptide; Ribonucleotide reductase R2 subunit; Ribonucleotide reductase small subunit; R2; RIR2; Ribonucleoside diphosphate reductase M2 chain; Ribonucleotide reductase small chain; RR2
Approved Symbol:
RRM2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 5
Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Cladribine(db);
  • Gallium nitrate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01587 Entrez Gene ID: 6241 OMIM ID: 180390 Swissprot Accession: P31350;