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Description for Protein RRM1

ribonucleotide reductase M1
5 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.17.4.1
KEGG - Orthology:
K10807
KEGG - Pathway(s):
hsa00230; hsa00240; hsa00480; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Ribonucleotide reductase M1 polypeptide; Ribonucleotide reductase large subunit; Ribonucleotide reductase R1 subunit; R1; RIR1; Ribonucleoside diphosphate reductase M1 chain; Ribonucleotide reductase large chain; RR1
Approved Symbol:
RRM1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 4
Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Cladribine(db);
  • Clofarabine(db);
  • Fludarabine(db);
  • Gemcitabine(db);
  • Hydroxyurea(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01588 Entrez Gene ID: 6240 OMIM ID: 180410 Swissprot Accession: P23921;