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Description for Protein RPS6KB2

ribosomal protein S6 kinase, 70kDa, polypeptide 2
17 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NES: Nuclear Export Signal
  • NLS: Nuclear localization signal
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • S_T_Y_Kinase: Protein kinase
  • unclassified specificity
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K04688
    KEGG - Pathway(s):
    hsa04012; hsa04150; hsa04350; hsa04666; hsa04910; hsa05221
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    EC 2.7.1.37; Ribosomal protein S6 kinase, 70kDa, polypeptide 2; p70S6Kb; P70-beta; S6K-beta 2; 70 kDa ribosomal protein S6 kinase 2; p70 ribosomal S6 kinase beta; Serine/threonine-protein kinase 14 beta; p70 S6Kbeta; STK14B; S6K2; S6 kinase-related kinase; SRK; Ribosomal protein S6 kinase, 70kDa, polypeptide 2 isoform a; Ribosomal protein S6 kinase, 70kDa, polypeptide 2 isoform b
    Approved Symbol:
    RPS6KB2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 11
    Human (de-) phosphorylation sites: 11; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 4
    Human phosphorylation targets: 4; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10203 Entrez Gene ID: 6199 OMIM ID: 608939 Swissprot Accession: Q9UBS0;