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Description for Protein RPS6KB1

ribosomal protein S6 kinase, 70kDa, polypeptide 1
48 total interacting proteins; 35 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K04688
    KEGG - Pathway(s):
    hsa04012; hsa04150; hsa04350; hsa04666; hsa04910; hsa05221
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    S6K1; S6K; p70-S6K; STK14A; Serine/Threonine Kinase 14 Alpha; Ribosomal Protein S6 Kinase
    Approved Symbol:
    RPS6KB1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 47
    Human phosphorylation targets: 19; Predicted platelet targets: 28
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10202 Entrez Gene ID: 6198 OMIM ID: 608938 Swissprot Accession: P23443;