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Description for Protein RPS6KA3

ribosomal protein S6 kinase, 90kDa, polypeptide 3
27 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 4)
Summary:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K04373
    KEGG - Pathway(s):
    hsa04010; hsa04114; hsa04150; hsa04720; hsa04722; hsa04914
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Ribosomal protein S6 kinase 3; RSK2; Ribosomal protein S6 kinase, 90-KD, 3; Ribosomal S6 kinase 2; S6K alpha 3; p90 RSK 3; Insulin stimulated protein kinase 1
    Approved Symbol:
    RPS6KA3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 28
    Human (de-) phosphorylation sites: 28; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 27
    Human phosphorylation targets: 26; Predicted platelet targets: 1
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Coffin-Lowry syndrome(Pd);
  • Mental retardation, X-linked 19(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02092 Entrez Gene ID: 6197 OMIM ID: 300075 Swissprot Accession: P51812;