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Description for Protein RPS6KA1

ribosomal protein S6 kinase, 90kDa, polypeptide 1
35 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 4)
Summary:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K04373
    KEGG - Pathway(s):
    hsa04010; hsa04114; hsa04150; hsa04720; hsa04722; hsa04914
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Ribosomal protein S6 kinase 90kDa polypeptide 1; RSK1; Ribosomal protein S6 kinase alpha 1; 90 kDa ribosomal protein S6 kinase 1; p90 RSK 1; MAPKAPK1a; RSK; HU 1; S6K-alpha 1; Ribosomal protein S6 kinase 90kD 1; EC 2.7.1.37; Ribosomal protein S6 kinase 90kDa polypeptide 1 isoform a; pp90RSK1; Ribosomal protein S6 kinase 90kDa polypeptide 1 isoform b
    Approved Symbol:
    RPS6KA1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 48
    Human (de-) phosphorylation sites: 48; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 72
    Human phosphorylation targets: 34; Predicted platelet targets: 40
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Purvalanol A(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03402 Entrez Gene ID: 6195 OMIM ID: 601684 Swissprot Accession: Q15418; A6NGG4;