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Description for Protein RORA

RAR-related orphan receptor A
19 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ZnF_C4: c4 zinc finger in nuclear hormone receptors
  • HOLI: Ligand binding domain of hormone receptors
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08532
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    RZR alpha; ROR alpha; RAR related orphan receptor alpha; RZRA; Retinoic acid binding receptor alpha; ROR1; ROR3; NR1F1; Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; RAR-related orphan receptor A isoform b; RAR-related orphan receptor A isoform c; RAR-related orphan receptor A isoform a; RAR-related orphan receptor A isoform d; ROR2; MGC119326; MGC119329; Transcription factor RZR-alpha; Retinoic acid receptor-related orphan receptor alpha
    Approved Symbol:
    RORA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Cholesterol(db);
  • Cholesterol-Sulfate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02896 Entrez Gene ID: 6095 OMIM ID: 600825 Swissprot Accession: P35398; Q495X4;