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Description for Protein ROCK1

Rho-associated, coiled-coil containing protein kinase 1
30 total interacting proteins; 22 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/2)
(microparticles: 1; platelet: 2; undefined: 1)
Summary:
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • PH: Pleckstrin homology domain.
  • HR1: Rho effector or protein kinase C-related kinase homology region 1 homologues
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K04514
    KEGG - Pathway(s):
    hsa04062; hsa04270; hsa04310; hsa04350; hsa04360; hsa04510; hsa04670; hsa04810; hsa05130; hsa05131
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    p160 ROCK; Rho associated coiled coil containing protein kinase 1; Rho kinase; ROK alpha; RhoA binding kinase
    Approved Symbol:
    ROCK1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 15
    Human (de-) phosphorylation sites: 15; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 28
    Human phosphorylation targets: 24; Predicted platelet targets: 4
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE(db);
  • (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE(db);
  • 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE(db);
  • HYDROXYFASUDIL(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03414 Entrez Gene ID: 6093 OMIM ID: 601702 Swissprot Accession: Q13464;