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Description for Protein RNASEL

ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ANK: ankyrin repeats
  • S_T_Y_Kinase: Protein kinase
  • unclassified specificity
  • PUG: domain in protein kinases, N-glycanases and other nuclear proteins
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.26.-
    KEGG - Orthology:
    K01165
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Ribonuclease 4; RNS4; RNase L; 2-5A-dependent RNase; 2-5A-dependent ribonuclease; HPC1; PRCA1; Interferon-induced 2-5A-dependent RNase; 2`,5`-oligoisoadenylate synthetase dependent; MGC104972; DKFZp781D08126
    Approved Symbol:
    RNASEL
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Prostate cancer, hereditary, 1(Pd);
  • Prostate cancer, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01590 Entrez Gene ID: 6041 OMIM ID: 180435 Swissprot Accession: Q5W0L2; Q05823;