Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein RNASE1

ribonuclease, RNase A family, 1 (pancreatic)
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.27.5
    KEGG - Orthology:
    K01168
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Ribonuclease, pancreatic; RNase A; RNase UpI-1; RNS1; RIB1; RNP; Ribonuclease, RNase A family, 1 (pancreatic); MGC12408; Pancreatic ribonuclease; EC 3.1.27.5; Pancreatic ribonuclease precursor
    Approved Symbol:
    RNASE1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-(2,5-dideoxy-5-pyrrolidin-1-yl-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione(db);
  • 1-(2-Deoxy-2-Fluoro-3-O-Phosphono-Beta-L-Ribofuranosyl)Pyrimidine-2,4(1h,3h)-Dione(db);
  • 1-(3-O-Phosphono-Beta-L-Arabinofuranosyl)Pyrimidine-2,4(1h,3h)-Dione(db);
  • 2'-Deoxycytidine-2'-Deoxyadenosine-3',5'-Monophosphate(db);
  • 2'-Deoxyuridine 3'-Monophosphate(db);
  • 2'-Monophosphoadenosine-5'-Diphosphate(db);
  • 2-Methyl-2,4-Pentanediol(db);
  • 2-Methyl-2-Propanol(db);
  • 3'-Phosphate-Adenosine-5'-Diphosphate(db);
  • 3'-Uridinemonophosphate(db);
  • 5'-deoxy-5'-piperidin-1-ylthymidine(db);
  • 5-Amino-1h-Pyrimidine-2,4-Dione(db);
  • Acetate Ion(db);
  • Adenosine-2'-5'-Diphosphate(db);
  • Adenosine-3'-5'-Diphosphate(db);
  • Adenosine-5'-Diphosphate(db);
  • Citric Acid(db);
  • Cysteine-S-Acetamide(db);
  • Cytidine-2'-Monophosphate(db);
  • Cytidine-3'-Monophosphate(db);
  • deoxycytidylyl-3',5'-guanosine(db);
  • Ester(db);
  • Formic Acid(db);
  • Guanidine(db);
  • Isopropyl Alcohol(db);
  • L-Aspartic Acid(db);
  • N-Formylmethionine(db);
  • Phosphoric Acid-2'-[2'-Deoxy-Uridine]Ester-5'-Guanosine Ester(db);
  • Purine Riboside-5'-Monophosphate(db);
  • U-Pi-a-Pi(db);
  • Uridine-2',3'-Vanadate(db);
  • Uridylyl-2'-5'-Phospho-Adenosine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01591 Entrez Gene ID: 6035 OMIM ID: 180440 Swissprot Accession: P07998;