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Description for Protein RHO

rhodopsin
11 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04250
    KEGG - Pathway(s):
    hsa04744
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Opsin 2; OPN2
    Approved Symbol:
    RHO
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (Hydroxyethyloxy)Tri(Ethyloxy)Octane(db);
  • 3-[Aminoethylphosphoryl]-[1,2-Di-Palmitoyl]-Sn-Glycerol(db);
  • Alpha-D-Mannose(db);
  • B-2-Octylglucoside(db);
  • B-Nonylglucoside(db);
  • B-Octylglucoside(db);
  • Beta-D-Mannose(db);
  • Halothane(db);
  • Heptane-1,2,3-Triol(db);
  • Heptyl 1-Thiohexopyranoside(db);
  • Hexadecanal(db);
  • Lauryl Dimethylamine-N-Oxide(db);
  • N-Acetylmethionine(db);
  • Palmitic Acid(db);
  • Phosphonoserine(db);
  • Phosphonothreonine(db)

    Associated Genetic Diseases:

  • Night blindness, congenital stationary, autosomal dominant 1(Pd);
  • Retinitis pigmentosa 4(Pd);
  • Retinitis pigmentosa, autosomal recessive(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 01584 Entrez Gene ID: 6010 OMIM ID: 180380 Swissprot Accession: P08100;