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Description for Protein RHEB

Ras homolog enriched in brain
15 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(microparticles: 1; platelet: 1)
Summary:
This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RAS: Ras subfamily of RAS small GTPases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07208
    KEGG - Pathway(s):
    hsa04150; hsa04910
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    RHEB2; GTP binding protein Rheb; Ras homolog enriched in brain
    Approved Symbol:
    RHEB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 2
    Human phosphorylation targets: 2; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Guanosine-5'-Diphosphate(db);
  • Guanosine-5'-Triphosphate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03188 Entrez Gene ID: 6009 OMIM ID: 601293 Swissprot Accession: Q15382;