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Description for Protein RHAG

Rh-associated glycoprotein
5 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is erythrocyte-specific and is thought to be part of a membrane channel that transports ammonium and carbon dioxide across the blood cell membrane. The encoded protein appears to interact with Rh blood group antigens and Rh30 polypeptides. Defects in this gene are a cause of regulator type Rh-null hemolytic anemia (RHN), or Rh-deficiency syndrome. (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06580
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Rhesus associated polypeptide, 50-KD; RH50A; RH2; Erythrocyte plasma membrane 50 kDa glycoprotein
    Approved Symbol:
    RHAG
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Rh-mod syndrome(Pd);
  • Rh-null hemolytic anemia, regulator type(Pd)
    		• Predicted Transmembrane Domains:
    01582_1(11)
    Additional Identifiers:

    HPRD: 01582 Entrez Gene ID: 6005 OMIM ID: 180297 Swissprot Accession: Q02094; Q96E98;