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Description for Protein RGS12

regulator of G-protein signaling 12
16 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RBD: Raf-like Ras-binding domain
  • PDZ: Domain present in PSD-95, Dlg, and ZO-1/2.
  • PTB: Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain
  • RGS: Regulator of G protein signalling domain
  • GoLoco: LGN motif, putative GEFs specific for G-alpha GTPases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Regulator of G-protein signalling 12 isoform 3; Regulator of G-protein signalling 12 isoform 2; RP11-529E10.1; DKFZp761K1617; DKFZp761K1817; Regulator of G-protein signalling 12 isoform 1
    Approved Symbol:
    RGS12
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 25
    Human (de-) phosphorylation sites: 25; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 7 : 0
  • Isoform 6 : 1
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03943 Entrez Gene ID: 6002 OMIM ID: 602512 Swissprot Accession: O14924;