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Description for Protein RGS3

regulator of G-protein signaling 3
19 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RGS: Regulator of G protein signalling domain
  • PDZ: Domain present in PSD-95, Dlg, and ZO-1/2.
  • C2: Protein kinase C conserved region 2 (CalB)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07524
    KEGG - Pathway(s):
    hsa04360
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    RGP3; C2PA; FLJ20370; PDZ-RGS3; FLJ31516; FLJ90496; Regulator of G-protein signalling 3 isoform 3; Regulator of G-protein signalling 3 isoform 2; Regulator of G-protein signalling 3 isoform 1; Regulator of G-protein signalling 3 isoform 4; Regulator of G-protein signalling 3 isoform 6
    Approved Symbol:
    RGS3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 12
    Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03720 Entrez Gene ID: 5998 OMIM ID: 602189 Swissprot Accession: P49796; B3KWG8; Q8WV02;