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Description for Protein RFX4

regulatory factor X, 4 (influences HLA class II expression)
4 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. This protein may be a transcriptional repressor rather than a transcriptional activator. Three transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • FH2: Formin Homology 2 Domain
  • ITAM: Immunoreceptor tyrosine-based activation motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09174
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Transcription factor NYD sp10; Regulatory factor X4 isoform c; Regulatory factor X4 isoform a; Regulatory factor X4 isoform b; Regulatory factor X4 isoform E; Regulatory factor X4 isoform F; Regulatory factor X4 isoform d
    Approved Symbol:
    RFX4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04905 Entrez Gene ID: 5992 OMIM ID: 603958 Swissprot Accession: Q33E94; B2RDW4;