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Description for Protein RFC5

replication factor C (activator 1) 5, 36.5kDa
17 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • AAA: ATPases associated with a variety of cellular activities
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10756
    KEGG - Pathway(s):
    hsa03030; hsa03420; hsa03430
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    RFC, 36.5 kD subunit; Activator 1 36 kDa subunit; A1 36 kDa subunit; RFC36; Replication factor C 5 isoform 1; Replication factor C 5 isoform 2; MGC1155; Replication factor C 5; Replication factor C (activator 1) 5 (36.5kD); Replication factor c, subunit 5; Replication factor C 36 kDa subunit; RF-C 36 kDa subunit
    Approved Symbol:
    RFC5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine-5'-Diphosphate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02677 Entrez Gene ID: 5985 OMIM ID: 600407 Swissprot Accession: P40937; A8MZ62;