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Description for Protein RFC2

replication factor C (activator 1) 2, 40kDa
16 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of this gene has been associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • AAA: ATPases associated with a variety of cellular activities
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10755
    KEGG - Pathway(s):
    hsa03030; hsa03420; hsa03430
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    RFC, 40 KD Subunit; Activator1 40 kDa subunit; A1 40 kDa subunit; RFC40; Replication factor C (activator 1) 2, 40kDa; MGC3665; A1; Replication factor C 2 (40kD) isoform 2; Replication factor C 2 (40kD) isoform 1
    Approved Symbol:
    RFC2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02675 Entrez Gene ID: 5982 OMIM ID: 600404 Swissprot Accession: P35250; Q75MT5;