Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein BCL2L1

BCL2-like 1
61 total interacting proteins; 30 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(membrane: 1; platelet: 12)
Summary:
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • BH4: BH4 Bcl-2 homology region 4
  • TM: Transmembrane domain
  • BCL: BCL (B-Cell lymphoma)
  • contains BH1, BH2 regions
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04570
    KEGG - Pathway(s):
    hsa04210; hsa04630; hsa05014; hsa05200; hsa05212; hsa05220; hsa05222
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    BCL2 like 1 isoform 2; BCL2 related gene; Apoptosis regulator Bcl-X; BCLX; BCL2L; Bcl-X; Bcl-xL; Bcl-xS; BCL-XL/S; DKFZp781P2092; Bcl-2-like 1 protein; BCL2-like 1 isoform 1
    Approved Symbol:
    BCL2L1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 02497 Entrez Gene ID: 598 OMIM ID: 600039 Swissprot Accession: Q07817; Q5TE63;