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Description for Protein RELA

v-rel reticuloendotheliosis viral oncogene homolog A (avian)
150 total interacting proteins; 51 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 2)
Summary:
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • IPT: ig-like, plexins, transcription factors
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04735
    KEGG - Pathway(s):
    hsa04010; hsa04062; hsa04210; hsa04620; hsa04621; hsa04622; hsa04623; hsa04660; hsa04662; hsa04722; hsa04920; hsa05120; hsa05131; hsa05140; hsa05142; hsa05200; hsa05212; hsa05215; hsa05220; hsa05221; hsa05222
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    V-Rel reticulondothelosis viral oncogene homolog A; Nuclear factor kappa-B, subunit 3; NFKB, p65 subunit; Nuclear factor of kappa light chain gene enhancer in B cells 3; MGC131774; p65; V-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit
    Approved Symbol:
    RELA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 21
    Human (de-) phosphorylation sites: 21; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01241 Entrez Gene ID: 5970 OMIM ID: 164014 Swissprot Accession: Q04206;