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Description for Protein RECQL

RecQ protein-like (DNA helicase Q1-like)
7 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the RecQ DNA helicase family. DNA helicases are enzymes involved in various types of DNA repair, including mismatch repair, nucleotide excision repair and direct repair. Some members of this family are associated with genetic disorders with predisposition to malignancy and chromosomal instability. The biological function of this helicase has not yet been determined. Two alternatively spliced transcripts, which encode the same isoform but differ in their 5' and 3' UTRs, have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • HELIC: helicase superfamily c-terminal domain
  • DEXDc: DEAD-like helicases superfamily
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.1.-
    KEGG - Orthology:
    K10899
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    RECQ1; RECQL1; DNA dependent ATPase Q1; DNA helicase RECQ like type 1; ATP dependent DNA helicase Q1; DNA helicase Q1-like; RecQ protein-like isoform 1
    Approved Symbol:
    RECQL
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02762 Entrez Gene ID: 5965 OMIM ID: 600537 Swissprot Accession: P46063;