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Description for Protein BCL2

B-cell CLL/lymphoma 2
89 total interacting proteins; 54 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • BH4: BH4 Bcl-2 homology region 4
  • BCL: BCL (B-Cell lymphoma)
  • contains BH1, BH2 regions
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K02161
    KEGG - Pathway(s):
    hsa04210; hsa04510; hsa04722; hsa05014; hsa05200; hsa05210; hsa05215; hsa05222
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    B-cell lymphoma protein 2 beta isoform; B-cell lymphoma protein 2 alpha isoform; B-cell lymphoma protein 2 alpha; Apoptosis regulator Bcl-2
    Approved Symbol:
    BCL2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Docetaxel(db);
  • Paclitaxel(db);
  • Rasagiline(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01045 Entrez Gene ID: 596 OMIM ID: 151430 Swissprot Accession: P10415; C9JHD5;