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Description for Protein RDH5

retinol dehydrogenase 5 (11-cis/9-cis)
3 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes an enzyme belonging to the short-chain dehydrogenases/reductases (SDR) family. This retinol dehydrogenase functions to catalyze the final step in the biosynthesis of 11-cis retinaldehyde, which is the universal chromophore of visual pigments. Mutations in this gene cause autosomal recessive fundus albipunctatus, a rare form of night blindness that is characterized by a delay in the regeneration of cone and rod photopigments. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.1.1.-
    KEGG - Orthology:
    K00061
    KEGG - Pathway(s):
    hsa00830
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Retinol dehydrogenase 1; RDH1; 11-cis retinol dehydrogenase; 11-cis RDH
    Approved Symbol:
    RDH5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • NADH(db);
  • Vitamin A(db)

    Associated Genetic Diseases:

  • Fundus albipunctatus, autosomal recessive(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03370 Entrez Gene ID: 5959 OMIM ID: 601617 Swissprot Accession: Q92781;