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Description for Protein RBBP6

retinoblastoma binding protein 6
14 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(secretome: 1)
Summary:
The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ZnF_C2HC: zinc finger
  • RING: Ring finger
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Proliferation potential related protein; RB binding Q protein 1; RBQ1; Retinoblastoma-binding protein 6 isoform 2; Retinoblastoma-binding protein 6 isoform 3; DKFZp761B2423; Retinoblastoma-binding protein 6 isoform 1
    Approved Symbol:
    RBBP6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 112
    Human (de-) phosphorylation sites: 112; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02964 Entrez Gene ID: 5930 OMIM ID: 600938 Swissprot Accession: Q147T5; Q7Z6E9;