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Description for Protein KDM5A

lysine (K)-specific demethylase 5A
13 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein which regulates cell proliferation. This protein also interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis. Rhombotin-2 is thought to either directly affect the activity of the encoded protein or may indirectly modulate the functions of the retinoblastoma protein by binding to this protein. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PHD: PHD zinc finger
  • CC: Coiled Coil
  • JmjN: Small domain found in the jumonji family of transcription factors
  • JMJC: A domain family that is part of the cupin metalloenzyme superfamily.
  • BRIGHT: BRIGHT, ARID (A/T-rich interaction domain) domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.11.-
    KEGG - Orthology:
    K11446
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    JUMONJI, AT-rich interactive domain 1A; RBBP2; RBP2; Retinoblastoma binding protein 2 isoform 1
    Approved Symbol:
    KDM5A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 18
    Human (de-) phosphorylation sites: 18; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08915 Entrez Gene ID: 5927 OMIM ID: 180202 Swissprot Accession: P29375; A8MUS2;