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Description for Protein RB1

retinoblastoma 1
176 total interacting proteins; 52 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K06618
KEGG - Pathway(s):
hsa04110; hsa05200; hsa05212; hsa05214; hsa05215; hsa05218; hsa05219; hsa05220; hsa05222; hsa05223
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
RB; OSRC; Retinoblastoma suspectibility protein; Retinoblastoma associated protein; PP110; P105-RB
Approved Symbol:
RB1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 35
Human (de-) phosphorylation sites: 35; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Insulin recombinant(db);
  • Insulin, porcine(db)

    Associated Genetic Diseases:

  • Pineoblastoma(Pd);
  • Retinoblastoma(Pd);
  • Retinoblastoma, incomplete penetrance type(Pd);
  • Small cell cancer of the lung(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01574 Entrez Gene ID: 5925 OMIM ID: 180200 Swissprot Accession: P06400;