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Description for Protein RASGRF1

Ras protein-specific guanine nucleotide-releasing factor 1
15 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RasGEF: Guanine nucleotide exchange factor for Ras-like small GTPases
  • CC: Coiled Coil
  • IQ: Short calmodulin-binding motif containing conserved Ile and Gln residues.
  • PH: Pleckstrin homology domain.
  • RHOGEF: Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
  • RasGEFN: Guanine nucleotide exchange factor for Ras-like GTPases
  • N-terminal motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04349
    KEGG - Pathway(s):
    hsa04010; hsa04510
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    GNRP; GRF1; CDC25; GRF55; CDC25L; Guanine nucleotide exchange factor; Guanine nucleotide releasing protein; Guanine nucleotide releasing factor 55 kDa; Ras specific nucleotide exchange factor Cdc25; Ras protein-specific guanine nucleotide-releasing factor 1 isoform 1; Ras protein-specific guanine nucleotide-releasing factor 1 isoform 2
    Approved Symbol:
    RASGRF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07362 Entrez Gene ID: 5923 OMIM ID: 606600 Swissprot Accession: Q8IUU5; Q13972; A8K270;